Rachelle Stark

UC Berkeley

“Exploring the Liver’s Role in Alzheimer’s Disease”

Notable microRNAs have been revealed as key regulators of metabolic homeostasis, serving as potential single targets to counter multiple aspects of metabolic diseases. Our mechanistic studies reveal that miR-128 acts to dysregulate energy expenditure programs, promoting fat storage and insulin resistance.

ABSTRACT

The incidence of obesity and type 2 diabetes (T2D) is rising rapidly worldwide, however there is an unmet need for new therapeutics. Notable microRNAs have been revealed as key regulators of metabolic homeostasis, serving as potential single targets to counter multiple aspects of metabolic diseases. Our mechanistic studies reveal that miR-128 acts to dysregulate energy expenditure programs, promoting fat storage and insulin resistance. We find that global knockout or antisense oligonucleotide (ASO) inhibition of miR-128 strongly protects mice from obesity and T2D. However, which tissues are most relevant and the exact mechanisms underlying the protective effects of miR-128 inhibition are unknown. Therefore, we are working to elucidate the molecular mechanisms by which a miR-128 ASO can treat obesity and T2D.
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