Amanda Carbajal

UC Santa Cruz

“Characterizing uropathogenic E.coli (UPEC) antibiotic resistance (ABR) conferring mutations and effects on drug binding interactions of fluoroquinolones”

Antibiotic resistance (ABR) is a worldwide public health crisis accelerated by overuse and misuse of antibiotics that select for randomly occurring genetic mutations. In the past 30 years there has been a decline in antibiotic efficiency and a rise in antibiotic resistant “superbugs”


Uropathogenic E.coli (UPEC) is one of the most common pathogens to infect humans, most%0D%0Apopular for causing urinary tract infections. If left untreated, UPEC can travel through the%0D%0Abladder, to the kidney, where it can hitch a ride in the renal artery, causing a globalized infection%0D%0Athrough the bloodstream, known as sepsis, which is incredibly challenging to treat.%0D%0AFluoroquinolones, the class of antibiotics used to treat UPEC worldwide, has been less effective%0D%0Ain recent years due to mutations that have arisen in their target enzymes, causing antibiotic%0D%0Aresistance. My research uses a multidisciplinary approach to uncover the mechanisms of action%0D%0Aof these mutations and how exactly they interfere with drug binding with respect to the unique%0D%0Achemical structure of fluoroquinolones.


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