Peter Andrew

UC Davis

“Natural history of acute and subchronic electrophysiologic responses to acute intoxication with the organophosphate diisopropylfluorophosphate (DFP) in male and female rats”

I study the processes that drive the development of epilepsy. In this project I use a highly sensitive technique to evaluate shifts in brain electrical activity in male and female rats that are exposed to a seizure-inducing chemical compound. I observe sex-independent changes in brain electrical activity and connectivity after this exposure, offering potential for development of translationally relevant biomarkers for clinical outcomes.

ABSTRACT

I use highly sensitive depth-electrode recording techniques to evaluate shifts in brain electrical activity in male and female rats that are exposed to a seizure-inducing chemical compound. These data offer several advances to my field. I observe that males and females respond comparably to this kind of exposure event. Additionally, I confirm previous reports that current therapeutic approaches for seizure treatment in this context are insufficient. Lastly, I observe dynamic shifts in coherence between brain regions, a measure of brain connectivity, following exposure to this class of seizure-inducing chemicals. Such altered connectivity has been associated with a number of adverse clinical outcomes, including cognitive impairment and the development of epilepsy. Our data advocate for the continued investigation of brain connectivity as an avenue for biomarker development and improved treatment of acute brain injury.
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