Kateryna Voitiuk

UC Santa Cruz

“Open-source platform for optogenetic stimulation of neurons integrated with high-density CMOS microelectrode recordings”

Electrical activity represents a functional readout of neural circuits, which we can monitor and perturb to understand how the neural network works. I created a hardware and software tool for delivering optogenetic perturbations to neural tissue during high-resolution electrical recording. With this platform, researchers can use optical stimulation to perturb neural circuits to study brain function and develop new treatments for neurological disorders.

ABSTRACT

Electrical activity represents a functional readout of neural circuits, which we can monitor and perturb to understand how the neural network works. Advances in biological tissue culture, computers, electrical recording and stimulation encourage software-driven experiments on neural tissue to accelerate our understanding of how the brain performs computation. I created a tool for stimulating and studying the effects of optogenetic perturbations on neural activity combined with high-resolution electrical recording. Using this platform, researchers can use optical stimulation to manipulate specific subtypes of neurons and observe how this affects activity in the network, providing insights into the role of different neuron subtypes in neural circuit function. Using off-the-shelf optoelectronic equipment and 3D printed components makes the platform accessible and reproducible for a broad community of researchers. This type of research has the potential to advance our understanding of the brain and could potentially lead to the development of new treatments for neurological disorders.
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