Monet Yuan

UC San Francisco

“Microbial Regulation of HIV Persistence in the Gut”

The gut harbors the largest HIV reservoir and is distinguished from other tissue sites by its complex and diverse microbiome. My research will identify specific microbial antigens and metabolites that influence the activity and survival of HIV reservoir cells, advancing fundamental knowledge about how the gut environment shapes HIV persistence. Ultimately, these discoveries aim to guide the development of novel microbiome-based interventions that can accelerate progress towards an HIV cure.

ABSTRACT

The superconducting Radio-frequency Quantum Upconverter (RQU) leverages the flux-dependent inductance of a three-junction interferometer to upconvert low-frequency signals (<300 MHz) to microwave frequencies (4 – 8 GHz), enabling sensitive quantum measurement protocols such as going beyond the Standard Quantum Limit and evading backaction noise. The RQU design incorporates a microwave resonator terminated by a Josephson junction interferometer, which is biased via inductively coupled flux loops. However, these flux bias ports can introduce loss and decoherence through parasitic coupling between the low-frequency flux bias and high-frequency flux signal lines, as well as coupling to parasitic resonance modes. I present a design to isolate the low-frequency bias lines from the flux signal lines and the high-frequency RF circuit. The analysis includes simulation of RQUs in Sonnet with an on-chip low-pass filter circuit, showing effective mitigation of losses to preserve the resonator’s coherence and quality factor. Applications include probing fundamental physics through the detection of axions, a leading candidate for dark matter.

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